England forward Saka picked up a knock in the 2-2 home draw with Tottenham Hotspur on Sunday in which he scored and made his 86th consecutive Premier League appearance - an Arsenal record.
Asked if Saka could miss Wednesday's League Cup third round trip to Brentford and league game at home to Bournemouth on Saturday, Arteta told reporters: "It's a possibility.
It is the situation that we have at the moment and we need players back, that's for sure," Arteta said.
"To change 11 or 12 players tomorrow, it is not a possibility," Arteta said.
"There are a lot of players that need minutes.
Persons:
Tony Obrien, Mikel Arteta, Saka, Arteta, hasn't, Declan Rice, Leandro Trossard, Gabriel Martinelli, Thomas Partey, Aadi Nair, Ken Ferris
Organizations:
Soccer Football, Premier League, Arsenal, Tottenham Hotspur, Emirates, League, Brentford, Bournemouth, Spurs, Thomson
Locations:
London, Britain, England, Bengaluru